Medicina di laboratorio pdf


 

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Medicina Di Laboratorio Pdf

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Precision medicine from experimental to clinical applications in oncology. Our understanding of the mechanisms of cancer development and progression has improved with the application of novel techniques that allow a comprehensive molecular tumour profiling. The application of discoveries and technologies from translational research to the clinical setting has facilitated the identification of novel drug targets and treatment strategies. It involves the use of biomarkers that provide unique patient- and tumour-specific molecular information. There has been a growing interest in cancer diagnostics using circulating tumour DNA as a source for tumour biomarkers. Liquid biopsy is less invasive than tumour biopsy, offering the potential to mirror the genetic diversity within a tumour, also enabling longitudinal measurements to monitor genetic changes in a tumour over time, avoiding re-biopsies. The use and improvement of these technologies will continue to advance the field of precision medicine by putting their application into standard clinical practice. Le evidenze precliniche e cliniche hanno permesso la conduzione di trial clinici di fase III che hanno incorporato alcuni di questi nuovi approcci personalizzati nella pratica clinica quotidiana, determinando in alcuni casi benefici significativi in termini di sopravvivenza. Infatti, i primi studi condotti con farmaci a bersaglio molecolare avevano arruolato popolazioni non selezionate di pazienti. Esistono due tipologie di biomarcatori predittivi. Infatti, i primi studi randomizzati condotti in popolazioni non selezionate di pazienti con CRC metastatico avevano evidenziato un vantaggio marginale per i pazienti che avevano ricevuto il farmaco anti-EGFR in combinazione con la chemioterapia rispetto alla sola chemioterapia2. In particolare, queste analisi hanno evidenziato un significativo vantaggio in termini di sopravvivenza libera da malattia per i soli pazienti che non hanno mutazioni di KRAS. Alcuni biomarcatori hanno un significato sia prognostico che predittivo, ma i due aspetti possono essere distinti. I risultati degli studi clinici randomizzati di fase III, in cui i pazienti sono stati trattati con farmaci anti-EGFR in combinazione con regimi di polichemioterapia, non hanno individuato nelle mutazioni di BRAF un fattore predittivo negativo4. Tuttavia, questi pazienti sono generalmente resistenti alla chemioterapia standard e, se le condizioni cliniche lo consentono, ricevono regimi chemioterapici intesivi.

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Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)

Manual of Otorhinolaryngology. Turin: Edizioni Minerva Medica; Gastroesophageal reflux disease. Surgical treatment of digestive diseases. Chicago: Year Book Medical Publishers; Recent advances in clinical neurophysiology.

Medicina di Laboratorio: un futuro possibile | SpringerLink

Amsterdam: Elsevier; Good enough: a primer on the analysis and interpretation of noninferiority trials. Ann Intern Med [Internet].

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Colon Cancer, Version 3 Available at www. Circulating mutant DNA to assess tumor dynamics. Nat Med ; The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers.

Nature ; Characterising the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment. Ann Oncol ; Detection of circulating tumor DNA in early- and late-stage tumor malignancies. Sci Transl Med ; 6: ra Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

Jones FS. I professionisti della Medicina di Laboratorio, la loro educazione istituzionale e continua, i contenuti professionali di cui dispongono sono sottoposti a radicali innovazioni.

Si tratta di immaginare il futuro con coraggio e con la prospettiva di saper cambiare profondamente i nostri saperi e i nostri modi di operare. Molte suggestioni degli autori citati in questo Editoriale possono essere utili. The transformation of Clinical Laboratory and Laboratory Medicine is breathtaking, full of opportunities cleverly disguised as challenges but potentially disruptive of discipline and professionals.

There is a need to imagine a future for Laboratory Medicine, with courage and awareness of the radical changing of knowledge and roles. Skip to main content Skip to sections. Advertisement Hide. Download PDF. Medicina di Laboratorio: Editoriale First Online: Laboratory Medicine: Download to read the full article text.

Clinical Diagnostic Technology. The Total Testing Process.

XIII ISVHLD 2016 - International symposium on viral hepatitis and liver disease

Volume 1: The Preanalytical Phase. Riv Ital Med Lab 8: Moving toward precision medicine The Lancet Cappelletti P Medicina di Laboratorio. In Galzigna L, Plebani M a cura di.