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Grooves Carl Fischer - Killer Grooves Advanced Levels Gary Chester - The New Breed 2 Billy Mintz - Different Drummers Special Interest Dom Famularo - The Weaker Side Ron Spagnardi - Cross-Sticking Studies Lorne Entress - Time And Drumming Ed Roscetti - Stuff!
Joe Morello - Master Studies 2 Bill Bachman - Stick Technique Vic Firth - Snaredrum Method Book 1 James Morton - The Virtuoso Drummer Carmine Appice - Rudiments To Rock Gordy Knudtson - Circular Rhythms Robert W. Buggert - Rubank Intermediate Method Drums Harvey S. Whistler - Rubank Advanced Method Drums Garwood Whaley - Basics In Rhythm Carl E. Charley Wilcoxon - Drum Method Charley Wilcoxon - Drumming!
These results suggest that differentiated cell identity determines susceptibility to transdifferentiation and highlight the importance of cellular context in controlling competency for reprogramming. Keywords: C.
Introduction A major goal in the study of development is to understand how the history of a cell determines its commitment to a final identity. Differentiated cells can be reprogrammed into induced pluripotent stem cells iPSCs or directly converted into other differentiated cell types by forced expression of transcription factors Tachibana et al.
The initial identity of the cell in combination with the set of transcription factors it expresses appears to determine the outcome of reprogramming. To what extent does the differentiated state of a cell predispose, or abrogate, its conversion into another cell type? Induced pluripotent stem cells IPSCs that have been obtained from many cell types more readily differentiate back into the lineage from which they were derived, evidence that the ancestral identity of a cell influences its subsequent redifferentiation Marchetto et al.
While much effort has been directed at reprogramming fibroblasts directly into distantly related cells forced transdifferentiation , such as melanocytes Tachibana et al.
It has been proposed that cells closely related in developmental lineage are more readily interconverted, as their expression states differ by a more limited number of factors Davis et al.
Cells that are related by lineage or position may also possess fail-safe mechanisms that maintain specific cell identities, thereby blocking their conversion to other cell fates as long as they remain in the same cellular environment.
In addition, some cells from diverse embryonic origins can converge on similar identities, indicating that cell lineage, including germ layer origin, is not an inviolable determinant of final identity.